Search results for "ibuprofen sodium"

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Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films

2020

AbstractThis study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two different concentrations of PVA (5% w/v and 7.5% w/v) were used. Solvent casting was used to prepare films, where a solution consisting of drug and polymer was cast and allowed to dry. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) were used to investigate the pr…

Materials sciencePolymersbuccal filmPharmaceutical ScienceIbuprofen02 engineering and technologyAquatic Science030226 pharmacology & pharmacyPolyvinyl alcohol03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDifferential scanning calorimetrySpectroscopy Fourier Transform InfraredDrug Discoveryibuprofen sodiumcrystallineSolubilityFourier transform infrared spectroscopyDissolutionPolyhydroxyethyl MethacrylateEcology Evolution Behavior and SystematicsAspartic AcidCalorimetry Differential ScanningEcologyGeneral MedicinePHEA021001 nanoscience & nanotechnologyAmidesSolventDrug LiberationMicrocrystallineSolubilitychemistryPolyvinyl AlcoholAttenuated total reflectionPVAMicroscopy Electron ScanningCrystallization0210 nano-technologyAgronomy and Crop ScienceResearch ArticleNuclear chemistry

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